No one in the DAN! community is able to decide in which direction the immune system may be dysregulated or which way it should be 'modulated'. It all sounds very scientific but if they can't tell up from down, hyper from hypo, or stimulate from suppress, it starts to sound like a big crap shoot. Let's just call it what it is: Immune-Tinkering. No different from fixing a CD player by randomly adjusting trim potentiometers on the laser block. You might get lucky and tweak the right one in the right direction on your first try but without the proper test equipment it's hit or miss. It's like asking a sex therapist for advice on immunology. Nobody would do that right?